Pub. Date : 2021 Oct
PMID : 34382727
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although the compensatory activation of PI3K/Akt survival signal has been proposed to cause the acquired lapatinib resistance; however, the comprehensive molecular mechanisms remain required to develop more efficient strategies to circumvent this therapeutic difficulty. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In this study, we found that suppression of HER2 by lapatinib still led to the Akt inactivation and elevation of FOX3a protein level but failed to induce the expression of their downstream pro-apoptotic effector p27kip1 , a cyclin-dependent kinase inhibitor. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |