Title : Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4.

Pub. Date : 2021 Oct

PMID : 34382282






3 Functional Relationships(s)
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1 Recently, GUN4 has been found to be able to bind the linear tetrapyrroles (bilins) and stimulate the magnesium chelatase activity in the unicellular green alga C. reinhardtii. Tetrapyrroles protein GENOMES UNCOUPLED 4 Arabidopsis thaliana
2 These linear molecules adopt a cyclic-helical conformation, and bind more tightly than planar porphyrins to the tetrapyrrole-binding pocket of GUN4. Tetrapyrroles protein GENOMES UNCOUPLED 4 Arabidopsis thaliana
3 Based on structural comparison, we propose a working model of GUN4 in regulation of tetrapyrrole biosynthetic pathway, and address the role of the bilin-bound GUN4 in retrograde signaling. Tetrapyrroles protein GENOMES UNCOUPLED 4 Arabidopsis thaliana