Title : Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.

Pub. Date : 2021 Aug 9

PMID : 34372885






1 Functional Relationships(s)
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1 RESULTS: Series 1: BI 1029539 or celecoxib reduced LPS-induced lung injury, with reduction in neutrophil influx, protein content, TNF-alpha, IL-1beta and PGE2 levels in bronchoalveolar lavage (BAL), myeloperoxidase activity, expression of mPGES-1, cyclooxygenase (COX)-2 and intracellular adhesion molecule in lung tissue compared with vehicle-treated mice. Celecoxib cytochrome c oxidase II, mitochondrial Mus musculus