Title : Magnoflorine Alleviates "M1" Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-κB Pathway and NLRP3 Inflammasome.

Pub. Date : 2021

PMID : 34366853






4 Functional Relationships(s)
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1 Magnoflorine Alleviates "M1" Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-kappaB Pathway and NLRP3 Inflammasome. magnoflorine NLR family pyrin domain containing 3 Homo sapiens
2 As a result, LPS evidently promoted the expression of pro-inflammatory cytokines and HMGB1, the MyD88-NF-kappaB activation, and the NLRP3 inflammasome profile in THP-1 cells, while MAG obviously inhibited the "M1"" polarization of THP-1 cells. magnoflorine NLR family pyrin domain containing 3 Homo sapiens
3 Furthermore, MAG dampened the HMGB1 expression and inactivated the MyD88/NF-kappaB pathway and NLRP3 inflammasome in NP cells. magnoflorine NLR family pyrin domain containing 3 Homo sapiens
4 In conclusion, this study confirmed that MAG alleviates "M1" polarized macrophage-mediated NP cell damage by inactivating the HMGB1-MyD88-NF-kappaB pathway and NLRP3 inflammasome, which provides a new reference for IDD treatment. magnoflorine NLR family pyrin domain containing 3 Homo sapiens