Pub. Date : 2021 Dec 5
PMID : 34363931
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway. | triptolide | microRNA 155 | Homo sapiens |
| 2 | AIM OF THE STUDY: The purpose of the study was to explore the role of miR-155, a microRNA closely related to various liver injuries and a regulator of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway, in TP-induced liver injury in vitro and in vivo. | triptolide | microRNA 155 | Homo sapiens |
| 3 | RESULTS: The results showed that TP significantly induced the expression of miR-155 both in L02 cells and in rodents liver tissue, and the inhibition of miR-155 could mitigate the hepatic damages caused by TP. | triptolide | microRNA 155 | Homo sapiens |
| 4 | RESULTS: The results showed that TP significantly induced the expression of miR-155 both in L02 cells and in rodents liver tissue, and the inhibition of miR-155 could mitigate the hepatic damages caused by TP. | triptolide | microRNA 155 | Homo sapiens |
| 5 | RESULTS: The results showed that TP significantly induced the expression of miR-155 both in L02 cells and in rodents liver tissue, and the inhibition of miR-155 could mitigate the hepatic damages caused by TP. | triptolide | microRNA 155 | Homo sapiens |
| 6 | RESULTS: The results showed that TP significantly induced the expression of miR-155 both in L02 cells and in rodents liver tissue, and the inhibition of miR-155 could mitigate the hepatic damages caused by TP. | triptolide | microRNA 155 | Homo sapiens |
| 7 | Further experiments demonstrated that the inhibition of miR-155 reversed the down-regulation of Nrf2 and HO-1 by TP, while the miR-155 mimic enhanced the effects of TP. | triptolide | microRNA 155 | Homo sapiens |
| 8 | Animal experiments also showed that the inhibition of miR-155 by miR-155 antagomir reversed the decrease of Nrf2 induced by TP administration. | triptolide | microRNA 155 | Homo sapiens |
| 9 | Animal experiments also showed that the inhibition of miR-155 by miR-155 antagomir reversed the decrease of Nrf2 induced by TP administration. | triptolide | microRNA 155 | Homo sapiens |
| 10 | CONCLUSIONS: These results indicated that miR-155 played an important role in TP-induced hepatotoxicity by regulating the Nrf2 signaling pathway. | triptolide | microRNA 155 | Homo sapiens |