Pub. Date : 2021 Jul 6
PMID : 34357109
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, it remains unclear whether single nucleotide polymorphisms (SNPs) that alter the sensitivity of the calcium-sensing receptor (CaSR) to circulating calcium are associated with primary and/or secondary neoplasms at specific pathological sites in patients of European and African ancestry. | Calcium | calcium sensing receptor | Homo sapiens |
| 2 | However, it remains unclear whether single nucleotide polymorphisms (SNPs) that alter the sensitivity of the calcium-sensing receptor (CaSR) to circulating calcium are associated with primary and/or secondary neoplasms at specific pathological sites in patients of European and African ancestry. | Calcium | calcium sensing receptor | Homo sapiens |
| 3 | Multivariable logistic regression models were used to analyze the association of CASR SNPs with circulating calcium, parathyroid hormone, vitamin D, and primary and secondary neoplasms. | Calcium | calcium sensing receptor | Homo sapiens |
| 4 | Interestingly, circulating calcium levels are higher in homozygous patients for the inactivating CASR variant at rs1801725 (TT genotype), and this is associated with a higher risk of secondary malignancies. | Calcium | calcium sensing receptor | Homo sapiens |
| 5 | Screening of patients for CASR variants at this locus may lead to improved management of high calcium associated tumor progression. | Calcium | calcium sensing receptor | Homo sapiens |