Title : Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway.

Pub. Date : 2021

PMID : 34349660






4 Functional Relationships(s)
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1 Glucagon-like peptide-1 receptor (GLP-1R) was downregulated by high glucose and overexpression of miR-192-5p and could be restored by dihydrotestosterone and Icariin. icariin glucagon-like peptide 1 receptor Rattus norvegicus
2 Glucagon-like peptide-1 receptor (GLP-1R) was downregulated by high glucose and overexpression of miR-192-5p and could be restored by dihydrotestosterone and Icariin. icariin glucagon-like peptide 1 receptor Rattus norvegicus
3 GLP-1R-siRNA transfection weakened the effects of Icariin on autophagy and fibrosis. icariin glucagon-like peptide 1 receptor Rattus norvegicus
4 These findings indicate that Icariin alleviates tubulointerstitial fibrosis by restoring autophagy through the miR-192-5p/GLP-1R pathway and is a novel therapeutic option for diabetic fibrosis. icariin glucagon-like peptide 1 receptor Rattus norvegicus