Title : Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

Pub. Date : 2021 Aug 12

PMID : 34342437






1 Functional Relationships(s)
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1 "Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique because the ligand (IC50 < 10 nM) is dramatically 1000-folds more cytotoxic than cisplatin in vitro. Cisplatin carbonic anhydrase 4 Homo sapiens