Pub. Date : 2021
PMID : 34335983
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Finally, we observed that metformin, a new anti-cancer drug, can significantly induce CCDC65 to suppress ENO1-AKT1 complex-mediated cell proliferation and EMT signals and finally suppresses the malignant phenotypes of gastric cancer cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Conclusion: These results firstly highlight a critical role of CCDC65 in suppressing ENO1-AKT1 pathway to reduce the progression of gastric cancer and reveals a new molecular mechanism for metformin in suppressing gastric cancer. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |