Title : Mutant Huntingtin Impairs Pancreatic β-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington's Disease.

Pub. Date : 2021 Dec

PMID : 34331233






2 Functional Relationships(s)
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1 Consequently, glucose stimulation failed to activate the downstream molecule phosphatidylinositol-3 kinase (PI3K) in 160Q cells, leading to reduced phosphorylation levels of serine-threonine protein kinase AKT and forkhead box protein O1 (FoxO1). Glucose thymoma viral proto-oncogene 1 Mus musculus
2 These data indicate that activation of the glucose-stimulated PI3K/AKT/FoxO1 signaling pathway is significantly blocked in pancreatic beta-cells in HD. Glucose thymoma viral proto-oncogene 1 Mus musculus