Title : Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry.

Pub. Date : 2021 Aug 11

PMID : 34328324






2 Functional Relationships(s)
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1 However, the molecular structures and glycan heterogeneity of the new O-glycans found on the S protein regional-binding domain (S-RBD) remain cryptic because of the challenges in intact glycoform analysis by conventional bottom-up glycoproteomic approaches. o-glycans surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 These findings demonstrate that this hybrid top-down MS approach can provide a high-resolution proteoform-resolved mapping of diverse O-glycoforms of the S glycoprotein, which lays a strong molecular foundation to uncover the functional roles of their O-glycans. o-glycans surface glycoprotein Severe acute respiratory syndrome coronavirus 2