Title : Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects.

Pub. Date : 2021 Sep

PMID : 34324828






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We also demonstrate the dissociation of organophosphate (OP)-conjugated dimers is reversed by structurally diverse oximes 2PAM, HI6 or RS194B, as demonstrated by SAXS of diethylphosphoryl-hAChE. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 However, binding of oximes to the native ligand-free hAChE, binding of high-affinity reversible ligands, or formation of a SP-sarin-hAChE conjugate had no effect on homodimerization. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens