Title : Case Report: Dexmedetomidine for Intractable Clusters of Myoclonic Jerks and Paroxysmal Sympathetic Hyperactivity in Progressive Encephalomyelitis With Rigidity and Myoclonus.

Pub. Date : 2021

PMID : 34322087






1 Functional Relationships(s)
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1 Conclusions: PERM is an immune-mediated disorder, but dexmedetomidine, a highly selective alpha2-adrenergic agonist, may alleviate paroxysmal symptoms by decreasing noradrenergic neuronal activity, resulting in attenuation of antibody-mediated disinhibited increased motor and sympathetic activity. Dexmedetomidine glycoprotein hormone subunit alpha 2 Homo sapiens