Pub. Date : 2021 Nov 1
PMID : 34311083
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. | TP-064 | coactivator-associated arginine methyltransferase 1 | Mus musculus |
| 2 | Here we investigated the effect of PRMT4 inhibitor TP-064 treatment on macrophage inflammation in vitro and in vivo. | TP-064 | coactivator-associated arginine methyltransferase 1 | Mus musculus |
| 3 | TP-064 treatment downregulated hepatic mRNA expression levels of the PRMT4 target genes glucose-6-phosphatase catalytic subunit (-50%, P<0.05) and the cyclin-dependent kinases 2 (-50%, P<0.05) and 4 (-30%, P<0.05), suggesting a direct transcriptional effect of PRMT4 also in hepatocytes. | TP-064 | coactivator-associated arginine methyltransferase 1 | Mus musculus |
| 4 | TP-064 treatment downregulated hepatic mRNA expression levels of the PRMT4 target genes glucose-6-phosphatase catalytic subunit (-50%, P<0.05) and the cyclin-dependent kinases 2 (-50%, P<0.05) and 4 (-30%, P<0.05), suggesting a direct transcriptional effect of PRMT4 also in hepatocytes. | TP-064 | coactivator-associated arginine methyltransferase 1 | Mus musculus |
| 5 | In conclusion, we have shown that the PRMT4 inhibitor TP-064 induces peritonitis-associated neutrophilia in vivo and inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo. | TP-064 | coactivator-associated arginine methyltransferase 1 | Mus musculus |