Title : Little in vitro effect of remdesivir on mitochondrial respiration and monoamine oxidase activity in isolated mitochondria.

Pub. Date : 2021 Oct 10

PMID : 34311047






1 Functional Relationships(s)
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1 At very high concentrations of RDV, there was partial inhibition of complex I- (IC50 675 micromol/L, residual activity 39.4 %) and complex II-linked (IC50 81.8 micromol/L, residual activity 40.7 %) respiration, without inhibition of complex IV-linked respiration, and partial inhibition both of MAO-A (IC50 26.6 micromol/L, residual activity 35.2 %) and MAO-B (IC50 89.8 micromol/L, residual activity 34.0 %) activity. remdesivir monoamine oxidase B Homo sapiens