Pub. Date : 2021
PMID : 34305617
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we proposed that remdesivir strongly binds to membrane protein (Mprotein), RNA-dependent RNA polymerase (RDRP), and main protease (Mprotease) of SARS-CoV-2. | remdesivir | myomesin 2 | Homo sapiens |
| 2 | It has been found that remdesivir binds to Mprotease, Mprotein, and RDRP with -7.8, -7.4, and -7.1 kcal/mol, respectively. | remdesivir | myomesin 2 | Homo sapiens |
| 3 | It has been found that strong binding of remdesivir to Mprotein leads to decrease in structural deviations and gyrations. | remdesivir | myomesin 2 | Homo sapiens |
| 4 | Furthermore, the eigenvalues and the trace of the covariance matrix were found to be low in case of Mprotease-remdesivir, Mprotein-remdesivir, and RDRP-remdesivir. | remdesivir | myomesin 2 | Homo sapiens |
| 5 | Binding of remdesivir to Mprotease, Mprotein, and RDRP reduces the average motions in protein due to its strong binding. | remdesivir | myomesin 2 | Homo sapiens |
| 6 | The MMPBSA calculations also suggested that remdesivir has strong binding affinity with Mprotein, Mprotease, and RDRP. | remdesivir | myomesin 2 | Homo sapiens |