Pub. Date : 2021 Oct
PMID : 34303036
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9. | Lysine | matrix metallopeptidase 2 | Homo sapiens |
| 2 | The synthesized biphenyl substituted lysine derivatives showed IC50-values in the low nanomolar concentration range against MMP-2 (ligands 3a-d: 3 nM to 8 microM, ligands 4a-d: 45 nM to 350 microM) and low micromolar range against MMP-9 (ligands 3a-d: 350 nM to 60 microM, ligands 4a-d: 5 microM to 600 microM), with a selectivity up to more than 160-fold for MMP-2. | Lysine | matrix metallopeptidase 2 | Homo sapiens |
| 3 | The synthesized biphenyl substituted lysine derivatives showed IC50-values in the low nanomolar concentration range against MMP-2 (ligands 3a-d: 3 nM to 8 microM, ligands 4a-d: 45 nM to 350 microM) and low micromolar range against MMP-9 (ligands 3a-d: 350 nM to 60 microM, ligands 4a-d: 5 microM to 600 microM), with a selectivity up to more than 160-fold for MMP-2. | Lysine | matrix metallopeptidase 2 | Homo sapiens |