Title : Association of somatic mutations in BRCA2 BRC domain with chemotherapy sensitivity and survival in high grade serous ovarian cancer.

Pub. Date : 2021 Sep 1

PMID : 34302857






2 Functional Relationships(s)
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1 We aimed to clarify whether BRCA2 BRC domain-associated mutation correlates with sensibility of platinum-based chemotherapy and survival in high-grade serous ovarian cancer(HGSOC). Platinum BRCA2 DNA repair associated Homo sapiens
2 CONCLUSIONS: Somatic mutations in BRCA2 BRC domain confer a higher sensitivity to platinum-based therapy and are associated with a favourable survival in HGSOC. Platinum BRCA2 DNA repair associated Homo sapiens