Pub. Date : 2021 Jul
PMID : 34302205
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Conophylline Suppresses Angiotensin II-Induced Myocardial Fibrosis In Vitro via the BMP4/JNK Pathway. | conophylline | bone morphogenetic protein 4 | Rattus norvegicus |
| 2 | Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself. | conophylline | bone morphogenetic protein 4 | Rattus norvegicus |
| 3 | Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself. | conophylline | bone morphogenetic protein 4 | Rattus norvegicus |
| 4 | Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself. | conophylline | bone morphogenetic protein 4 | Rattus norvegicus |
| 5 | Conophylline produced no effect on phosphorylation of alpha-SMA and Smad homologue-1/5/8, the classic BMP4 downstream pathway elements, but reduced the level of c-Jun N-terminal kinase (JNK) elevated by BMP4. | conophylline | bone morphogenetic protein 4 | Rattus norvegicus |
| 6 | Thus, conophylline inhibited angiotensin II-provoked myocardial fibrosis via the BMP4/JNK pathway. | conophylline | bone morphogenetic protein 4 | Rattus norvegicus |