Title : The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene.

Pub. Date : 2021 Jul 22

PMID : 34294164






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Nonsynonymous single-nucleotide polymorphisms in LTBP4 gene associate with prolonged ambulation in DMD patients, whereas an in-frame insertion polymorphism in the mouse LTBP4 locus modulates disease severity in mice by altering proteolytic stability of the Ltbp4 protein and release of transforming growth factor-beta (TGF-beta). single-nucleotide latent transforming growth factor beta binding protein 4 Homo sapiens