Title : New Catalytic Radical Process Involving 1,4-Hydrogen Atom Abstraction: Asymmetric Construction of Cyclobutanones.

Pub. Date : 2021 Aug 4

PMID : 34292709






1 Functional Relationships(s)
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1 Supported by an optimal chiral ligand, the Co(II)-based metalloradical system, which operates under mild conditions, is capable of 1,4-C-H alkylation of alpha-aryldiazoketones with varied electronic and steric properties to construct chiral alpha,beta-disubstituted cyclobutanones in good to high yields with high diastereoselectivities and enantioselectivities, generating dinitrogen as the only byproduct. Nitrogen mitochondrially encoded cytochrome c oxidase II Homo sapiens