Title : Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.

Pub. Date : 2021 Oct

PMID : 34291435






2 Functional Relationships(s)
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1 We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKalpha/beta signaling that leads to phosphorylation of Ser85 of the key mediator of CMA, Hsc70, and its activation. Metformin conserved helix-loop-helix ubiquitous kinase Mus musculus
2 Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKalpha/beta-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases, such as AD, where such therapeutic intervention could be beneficial. Metformin conserved helix-loop-helix ubiquitous kinase Mus musculus