Title : CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB.

Pub. Date : 2021 Jul

PMID : 34283874






4 Functional Relationships(s)
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1 Using proteome analysis and real-time qPCR assay, we found that cbs expression could stimulate the expression of several enzymatic antioxidants, including reactive oxygen species (ROS) detoxifying enzymes SodB, KatG and AhpC, the DNA protective protein DPS and the protein redox regulator Trx1. Reactive Oxygen Species cystathionine beta-synthase Mus musculus
2 Using proteome analysis and real-time qPCR assay, we found that cbs expression could stimulate the expression of several enzymatic antioxidants, including reactive oxygen species (ROS) detoxifying enzymes SodB, KatG and AhpC, the DNA protective protein DPS and the protein redox regulator Trx1. Reactive Oxygen Species cystathionine beta-synthase Mus musculus
3 Assays of ROS detoxification capacities revealed that CBS-derived H2S could promote catalase activity at the post-translational level, especially for KatB, which serves as an important way that endogenous H2S participates in H2O2 detoxification. Reactive Oxygen Species cystathionine beta-synthase Mus musculus
4 Herein, we proposed that V. cholerae regulates CBS-dependent H2S production for better survival and proliferation under ROS stress. Reactive Oxygen Species cystathionine beta-synthase Mus musculus