Title : IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development.

Pub. Date : 2021 Jul 16

PMID : 34282122






1 Functional Relationships(s)
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1 Moreover, both AMP-activated protein kinase (AMPK) agonist metformin and two mammalian targets of rapamycin (mTOR) inhibitors (INK128 and rapamycin) inhibited the percentage of M-MDSCs in lupus mice as well as in the TLR7- and IFN-alpha-induced bone marrow (BM) differentiation into MDSCs in vitro. Metformin interferon alpha Mus musculus