Title : Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents.

Pub. Date : 2021 Dec

PMID : 34281458






1 Functional Relationships(s)
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1 The overall results demonstrated that substitution of the phenylethyloxy moiety at the 7-position imparted superior general activity to the derivatives, with the propargylamine substitution at the 3-position, in particular, displaying the best MAO-B selectivity and neuroprotection. propargylamine monoamine oxidase B Homo sapiens