Title : Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells.

Pub. Date : 2021 Jul 5

PMID : 34281282






3 Functional Relationships(s)
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1 Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells. Acrolein AKT serine/threonine kinase 1 Homo sapiens
2 Acrolein suppressed the phosphorylation of glucose metabolic signals IRS1, Akt, mTOR, p70S6K, and GSK3alpha/beta. Acrolein AKT serine/threonine kinase 1 Homo sapiens
3 Over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes. Acrolein AKT serine/threonine kinase 1 Homo sapiens