Title : Potent Neutralizing Antibodies Elicited by RBD-Fc-Based COVID-19 Vaccine Candidate Adjuvanted by the Th2-Skewing iNKT Cell Agonist.

Pub. Date : 2021 Aug 12

PMID : 34279930






1 Functional Relationships(s)
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1 alpha-Galactosylceramide (alphaGC) is a classical iNKT cell agonist which causes the rapid production of Th1- and Th2-associated cytokines; we, therefore, expect that the Th1- or Th2-skewing analogues of alphaGC can better enhance the immunogenicity of the receptor-binding domain in the spike protein of SARS-CoV-2 fused with the Fc region of human IgG (RBD-Fc). alpha-galactosylceramide surface glycoprotein Severe acute respiratory syndrome coronavirus 2