Pub. Date : 2021
PMID : 34277607
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidative Stress Activated by Sorafenib Alters the Temozolomide Sensitivity of Human Glioma Cells Through Autophagy and JAK2/STAT3-AIF Axis. | Sorafenib | apoptosis inducing factor mitochondria associated 1 | Homo sapiens |
| 2 | Mechanistically, the combination of sorafenib and TMZ induced mitochondrial depolarization and apoptosis inducing factor (AIF) translocation from mitochondria to nuclei, and this process was dependent on STAT3 inhibition. | Sorafenib | apoptosis inducing factor mitochondria associated 1 | Homo sapiens |
| 3 | Mechanistically, the combination of sorafenib and TMZ induced mitochondrial depolarization and apoptosis inducing factor (AIF) translocation from mitochondria to nuclei, and this process was dependent on STAT3 inhibition. | Sorafenib | apoptosis inducing factor mitochondria associated 1 | Homo sapiens |
| 4 | The results indicate that sorafenib enhanced the temozolomide sensitivity of human glioma cells by inducing oxidative stress-mediated autophagy and JAK2/STAT3-AIF axis. | Sorafenib | apoptosis inducing factor mitochondria associated 1 | Homo sapiens |