Pub. Date : 2021 Oct
PMID : 34271087
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NADPH is a cofactor used by reactive oxygen species (ROS) scavenging enzymes to block ROS produced in cells. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 2 | NADPH is a cofactor used by reactive oxygen species (ROS) scavenging enzymes to block ROS produced in cells. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 3 | NADPH is a cofactor used by reactive oxygen species (ROS) scavenging enzymes to block ROS produced in cells. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 4 | Therefore, we hypothesized that IDH2, a major NADPH-producing enzyme in mitochondria is ubiquitinated for ROS to increase in mitosis. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 5 | To understand the link between IDH2 ubiquitination and ROS produced in mitosis, we show that overexpressing mitochondria-targeted-IDH1 decreased ROS by increasing NADPH in IDH2 ubiquitinated cells. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 6 | We conclude that APC/C CDH1 ubiquitinates IDH2, a major NADPH-producing enzyme in mitochondria contributing to ROS increase in mitosis. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |