Title : Atrial Natriuretic Peptide Promotes Neurite Outgrowth and Survival of Cochlear Spiral Ganglion Neurons in vitro Through NPR-A/cGMP/PKG Signaling.

Pub. Date : 2021

PMID : 34268307






3 Functional Relationships(s)
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1 Our recently published investigation revealed that ANP could promote the neurite outgrowth of SGNs by activating NPR-A/cGMP/PKG cascade in a dose-dependent manner. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens
2 Our data indicated that ANP could support and attract neurite outgrowth of SGNs and possess a high capacity to improve neuronal survival of SGNs against glutamate-induced excitotoxicity by triggering the NPR-A/cGMP/PKG pathway. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens
3 The neuroregenerative and neuroprotective effects of ANP/NPRA/cGMP/PKG-dependent signaling on SGNs would represent an attractive therapeutic candidate for hearing impairment. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens