Title : 3D-printed titanium implant combined with interleukin 4 regulates ordered macrophage polarization to promote bone regeneration and angiogenesis.

Pub. Date : 2021 Jul

PMID : 34259564






5 Functional Relationships(s)
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1 METHODS: IL4 at concentrations of 0, 30, and 100 ng/ml was used at day 3 to create a biomimetic environment for bone marrow mesenchymal stromal cell (BMMSC) osteogenesis and macrophage polarization on the DT. Thymidine interleukin 4 Homo sapiens
2 RESULTS: DT plus 30 ng/ml of IL4 (DT + 30 IL4) from day 3 to day 7 significantly (p < 0.01) enhanced macrophage type 2 polarization and BMMSC osteogenesis compared with the other groups. Thymidine interleukin 4 Homo sapiens
3 RESULTS: DT plus 30 ng/ml of IL4 (DT + 30 IL4) from day 3 to day 7 significantly (p < 0.01) enhanced macrophage type 2 polarization and BMMSC osteogenesis compared with the other groups. Thymidine interleukin 4 Homo sapiens
4 Local injection of IL4 enhanced new bone formation surrounding the DT. Thymidine interleukin 4 Homo sapiens
5 CONCLUSION: DT + 30 IL4 may switch macrophage polarization at the appropriate timepoints to promote bone regeneration. Thymidine interleukin 4 Homo sapiens