Title : The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-α Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway.

Pub. Date : 2021

PMID : 34257809






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-alpha Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway. Curcumin AKT serine/threonine kinase 1 Homo sapiens
2 Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation. Curcumin AKT serine/threonine kinase 1 Homo sapiens
3 A combined treatment of curcumin and probucol could be used to protect chondrocytes from inflammatory cytokine stress via inhibition of the autophagy-related PI3K/Akt/mTOR pathway both in vitro and in vivo, which might be of potential pharmaceutical value for OA prevention and therapy. Curcumin AKT serine/threonine kinase 1 Homo sapiens