Title : Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis.

Pub. Date : 2021 Aug

PMID : 34247189






1 Functional Relationships(s)
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1 The synergy between Terbinafine and sorafenib was due to concomitant inhibition of mTORC1 and induction of severe persistent DNA double-strand breaks (DSBs), which led to the delayed proliferation and accelerated cell death. Sorafenib CREB regulated transcription coactivator 1 Mus musculus