Title : Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/β-catenin signaling pathways.

Pub. Date : 2021

PMID : 34227646






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/beta-catenin signaling pathways. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
2 Additionally, RSV-induced deactivation of the PI3K/AKT and Wnt/beta-catenin pathways in LPS-induced HGFs was observed by western blot analysis. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
3 Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
4 These results suggested RSV attenuated the inflammation and OS injury of P. gingivalis LPS-treated HGFs by deactivating the PI3K/AKT and Wnt/beta-catenin signaling pathways. Resveratrol AKT serine/threonine kinase 1 Homo sapiens