Pub. Date : 2021 Sep
PMID : 34224824
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isotretinoin is associated with pro-apoptotic signaling in sebaceous glands through upregulated expression of p53, forkhead box O transcription factors (FOXO1, FOXO3), and tumor necrosis factor-related apoptosis inducing ligand (TRAIL). | Isotretinoin | forkhead box O1 | Homo sapiens |
| 2 | Two literature searches including clinical and experimental studies respectively support the hypothesis that isotretinoin s toxicological mode of action on the pituitary-ovarian axis might be caused by over-expressed p53/FOXO1 signaling resulting in gonadotropin suppression and granulosa cell apoptosis. | Isotretinoin | forkhead box O1 | Homo sapiens |