Pub. Date : 2021 Aug
PMID : 34210658
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed ALK F1174L-mutated neuroblastoma. | lorlatinib | ROS proto-oncogene 1, receptor tyrosine kinase | Homo sapiens |
| 2 | We describe a case of a patient with relapsed, refractory, metastatic ALK F1174L-mutated neuroblastoma who showed no response to the first generation ALK inhibitor crizotinib but had a subsequent complete response to the ALK/ROS1 inhibitor lorlatinib. | lorlatinib | ROS proto-oncogene 1, receptor tyrosine kinase | Homo sapiens |