Title : ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin.

Pub. Date : 2021 Jun 7

PMID : 34200372






2 Functional Relationships(s)
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1 The glycosaminoglycans heparan sulphate and dermatan sulphate, but not chondroitin sulphate, also inhibited the binding of spike protein, indicating that it might bind to one or both of these glycosaminoglycans on the surface of target cells. Glycosaminoglycans surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 The glycosaminoglycans heparan sulphate and dermatan sulphate, but not chondroitin sulphate, also inhibited the binding of spike protein, indicating that it might bind to one or both of these glycosaminoglycans on the surface of target cells. Glycosaminoglycans surface glycoprotein Severe acute respiratory syndrome coronavirus 2