CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin.	Heparin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
2	As the spike protein has previously been shown to bind heparin, a soluble glycosaminoglycan, we tested the effects of various heparins on ACE2-independent spike protein interaction with cells.	Heparin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
3	Unfractionated heparin inhibited spike protein interaction with an IC50 value of <0.05 U/mL, whereas two low-molecular-weight heparins were less effective.	Heparin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
4	A mutant form of the spike protein, lacking the arginine-rich putative furin cleavage site, interacted only weakly with cells and had a lower affinity for unfractionated and low-molecular-weight heparin than the wild-type spike protein.	Heparin	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2