Title : Effect of Genetic Variability in 20 Pharmacogenes on Concentrations of Tamoxifen and Its Metabolites.

Pub. Date : 2021 Jun 4

PMID : 34199712






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Endoxifen is the most-studied active tamoxifen metabolite, and endoxifen concentrations are highly associated with CYP2D6 activity. Tamoxifen cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 CYP2D6 was the primary gene associated with the tamoxifen metabolism pathway, especially the conversion of tamoxifen to endoxifen. Tamoxifen cytochrome P450 family 2 subfamily D member 6 Homo sapiens
3 CYP2D6 was the primary gene associated with the tamoxifen metabolism pathway, especially the conversion of tamoxifen to endoxifen. Tamoxifen cytochrome P450 family 2 subfamily D member 6 Homo sapiens