Title : Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in the brain without affecting that in intestine.

Pub. Date : 2021 Nov 5

PMID : 34198150






2 Functional Relationships(s)
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1 In this study, we characterized a new backbone of the AChE/GSK3beta inhibitor 11c. Carbon-11 acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In vivo studies confirmed that 11c significantly inhibited the activity of AChE in the brain but had little effect on the activity of AChE in the intestine. Carbon-11 acetylcholinesterase (Cartwright blood group) Homo sapiens