Title : Inhibition of human UDP-glucuronosyltransferase enzyme by Dabrafenib: Implications for drug-drug interactions.

Pub. Date : 2021 Nov

PMID : 34192355






2 Functional Relationships(s)
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1 METHODS: The formation rates for 4-methylumbelliferone (4-MU) glucuronide and trifluoperazine-glucuronide in 12 recombinant human UGT isoforms with or without dabrafenib were measured, and HPLC was used to investigate the inhibitory effects of dabrafenib on UGTs. Glucuronides UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
2 METHODS: The formation rates for 4-methylumbelliferone (4-MU) glucuronide and trifluoperazine-glucuronide in 12 recombinant human UGT isoforms with or without dabrafenib were measured, and HPLC was used to investigate the inhibitory effects of dabrafenib on UGTs. Glucuronides UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens