Title : The IL-6/STAT Signaling Pathway and PPARĪ± Are Involved in Mediating the Dose-Dependent Cardioprotective Effects of Fenofibrate in 5-Fluorouracil-Induced Cardiotoxicity.

Pub. Date : 2021 Jun 29

PMID : 34185243






1 Functional Relationships(s)
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1 RESULTS: The current study showed that 5FU succeeded in inducing cardiotoxicity, manifested by significantly elevated levels of cardiac enzymes, tissue malondialdehyde (MDA), interleukin 6 (IL-6), signal transducer and activator of transcription 4 (STAT4), and caspase-3. Fluorouracil caspase 3 Homo sapiens