Pub. Date : 2021 Jun 28
PMID : 34182874
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: In this research, to explore the effect of HCQ for angiogenesis, we investigated: (1) Human umbilical vein endothelial cells (HUVECs) viability by CCK-8; (2) HUVECs migration by wound healing; (3) HUVEC angiogenesis by Matrigel assay in vitro; (4) mRNA expression of MMP-2 and VEGF by real-time quantitative Polymerase Chain Reaction (RT-PCR); (5) protein expression of VEGF, MMP-2 by western blot. | Hydroxychloroquine | matrix metallopeptidase 2 | Homo sapiens |
| 2 | METHODS: In this research, to explore the effect of HCQ for angiogenesis, we investigated: (1) Human umbilical vein endothelial cells (HUVECs) viability by CCK-8; (2) HUVECs migration by wound healing; (3) HUVEC angiogenesis by Matrigel assay in vitro; (4) mRNA expression of MMP-2 and VEGF by real-time quantitative Polymerase Chain Reaction (RT-PCR); (5) protein expression of VEGF, MMP-2 by western blot. | Hydroxychloroquine | matrix metallopeptidase 2 | Homo sapiens |
| 3 | RESULTS: We found that HCQ treatment significantly restored the expression of aPL-inhibited VEGF and MMP-2. | Hydroxychloroquine | matrix metallopeptidase 2 | Homo sapiens |