Title : Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.

Pub. Date : 2021 Jun 25

PMID : 34172715






4 Functional Relationships(s)
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1 The coenzyme nicotinamide adenine dinucleotide (NAD+) is essential for both mitochondrial bioenergetics and nuclear DNA repair through NAD+-consuming poly (ADP-ribose) polymerases (PARPs). NAD Poly-(ADP-ribose) polymerase Drosophila melanogaster
2 The coenzyme nicotinamide adenine dinucleotide (NAD+) is essential for both mitochondrial bioenergetics and nuclear DNA repair through NAD+-consuming poly (ADP-ribose) polymerases (PARPs). NAD Poly-(ADP-ribose) polymerase Drosophila melanogaster
3 We suggest that enhancing the availability of NAD+ by either vitamin B supplements or the inhibition of NAD+-dependent enzymes such as PARPs are potential therapies for Alzheimer"s disease. NAD Poly-(ADP-ribose) polymerase Drosophila melanogaster
4 We suggest that enhancing the availability of NAD+ by either vitamin B supplements or the inhibition of NAD+-dependent enzymes such as PARPs are potential therapies for Alzheimer"s disease. NAD Poly-(ADP-ribose) polymerase Drosophila melanogaster