Title : Xanthine oxidoreductase promotes the progression of colitis-associated colorectal cancer by causing DNA damage and mediating macrophage M1 polarization.

Pub. Date : 2021 Sep 5

PMID : 34171392






1 Functional Relationships(s)
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1 Mechanistically, TNFalpha may activate XOR transcription via activator protein-1 and, thus, promote endogenous hydrogen peroxide generation, resulting in oxidative DNA damage in colon cancer cells. Hydrogen Peroxide tumor necrosis factor Homo sapiens