Title : Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis.

Pub. Date : 2021 May-Jun

PMID : 34169921






1 Functional Relationships(s)
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1 The results show that, CM, SP, and UB can inhibit the RGMCs proliferation to attenuate the ECM proliferation and cell hypertrophy, reduced the accumulation of ECM protein fibronectin, and lowered the expression of the key fibrosis factor TGF-beta and CTGF to inhibit the kidney fibrosis and thereby improved diabetic glomerulosclerosis. 7-hydroxycoumarin transforming growth factor alpha Rattus norvegicus