Title : Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy.

Pub. Date : 2021 Oct 28

PMID : 34166767






2 Functional Relationships(s)
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1 PCK2 inhibition in sorafenib-resistant cells significantly reversed drug resistance in vitro and in vivo. Sorafenib phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens
2 High levels of PCK2 predicted a shorter progression-free survival time in patients who received sorafenib treatment. Sorafenib phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens