Pub. Date : 2021 Sep
PMID : 34165800
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Candidate gene studies of smoking phenotypes have identified several pharmacogenes implicated in nicotine"s pharmacokinetics (CYP2A6, CYP2B6, CYP2A13, FMOs, UGTs, and OCT2), and nicotine"s pharmacodynamic response in the central nervous system (nicotinic acetylcholine receptors, as well as through the dopaminergic and serotonergic systems). | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | The genes CYP2A6 and the CHRNA5-A3-B4 confer the most replicated sources of genetic variation in smoking behaviours, likely due to their importance in nicotine"s pharmacology. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |