Title : A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides.

Pub. Date : 2021 Jun 24

PMID : 34165649






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Although structurally and mechanistically similar to the human lysosomal alpha-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward alpha-N-acetylglucosamine-terminated heparosan oligosaccharides, the preferred substrates of hNAGLU. Heparitin Sulfate N-acetyl-alpha-glucosaminidase Homo sapiens
2 Although structurally and mechanistically similar to the human lysosomal alpha-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward alpha-N-acetylglucosamine-terminated heparosan oligosaccharides, the preferred substrates of hNAGLU. Heparitin Sulfate N-acetyl-alpha-glucosaminidase Homo sapiens
3 This bacterial alpha-N-acetylglucosaminidase could be a useful catalyst for heparan sulfate analysis. Heparitin Sulfate N-acetyl-alpha-glucosaminidase Homo sapiens