Pub. Date : 2021 Sep
PMID : 34159680
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We established a sorafenib-resistant Huh7 (human HCC) cell line, and characterized it with cytokine assays, then developed CAFs by co-culturing human hepatic stellate cells with resistant or parental Huh7 cells. | Sorafenib | MIR7-3 host gene | Homo sapiens |
| 2 | The sorafenib-resistant Huh7 (Huh7SR ) cells expressed increased B-cell activating factor (BAFF), which promoted highly expression of CAF specific markers in Huh7SR -co-cultured CAFs, showed activated BAFF, BAFF-R and downstream NFkappaB-Nrf2 pathway, and aggravated invasion, migration and drug resistance in co-cultured Huh7 cells. | Sorafenib | MIR7-3 host gene | Homo sapiens |
| 3 | The sorafenib-resistant Huh7 (Huh7SR ) cells expressed increased B-cell activating factor (BAFF), which promoted highly expression of CAF specific markers in Huh7SR -co-cultured CAFs, showed activated BAFF, BAFF-R and downstream NFkappaB-Nrf2 pathway, and aggravated invasion, migration and drug resistance in co-cultured Huh7 cells. | Sorafenib | MIR7-3 host gene | Homo sapiens |
| 4 | The sorafenib-resistant Huh7 (Huh7SR ) cells expressed increased B-cell activating factor (BAFF), which promoted highly expression of CAF specific markers in Huh7SR -co-cultured CAFs, showed activated BAFF, BAFF-R and downstream NFkappaB-Nrf2 pathway, and aggravated invasion, migration and drug resistance in co-cultured Huh7 cells. | Sorafenib | MIR7-3 host gene | Homo sapiens |
| 5 | The sorafenib-resistant Huh7 (Huh7SR ) cells expressed increased B-cell activating factor (BAFF), which promoted highly expression of CAF specific markers in Huh7SR -co-cultured CAFs, showed activated BAFF, BAFF-R and downstream NFkappaB-Nrf2 pathway, and aggravated invasion, migration and drug resistance in co-cultured Huh7 cells. | Sorafenib | MIR7-3 host gene | Homo sapiens |